nat cell biolnature review cancer

  • Nature Reviews Molecular Cell Biology Impact Factor IF

    Nature Reviews Molecular Cell Biology Impact Factor, IF, number of article, detailed information and journal factor. ISSN .

  • Mechanisms of Tumor Cell–Intrinsic Immune Evasion

     · The immune system has the potential to recognize and eliminate tumor cells, and failed immune surveillance contributes to cancer development. Many immunotherapeutics, including checkpoint blockade therapy, harness the endogenous antitumor immune response. While clinical benefit can be profound in some cases, some patients show primary resistance, whereas others experience clinical

  • Metabolic Frugality Marks Cancer Cells Home Cell Press

     · Altered cell metabolism is ubiquitous in cancer cells however, it remains challenging to exploit these alterations for cancer therapy. A new study reveals that metabolic alterations to the urea cycle promote tumor growth but unexpectedly also trigger mutations that mark cancer

  • New Single-Cell Sequencing Method Cancer Network

     · According to research published in Nature Communications, investigators developed a new single-cell multi-omic approach to identify leukemic stem cells and characterized cancer stem cells in the context of acute myeloid leukemia (AML), which the investigators think may be able to translate to other tumor types. 1. MutaSeq, the new method created by investigators from the Centre for Genomic

  • Berberine as a cancer treatment CANCERactive

     · Berberine has been shown in research to work along a number of quite separate pathways against cancer it reduces blood sugar levels, it reduces inflammation, boosts immune response and attacks the energy production system (the AMPK pathway) of cancer cells weakening the cancer cells, and helping chemotherapy it also kills microbes in the gut and cuts blood fats and blood pressure.

  • The Two Faces of Reactive Oxygen Species in Cancer

     · Reactive oxygen species (ROS), now appreciated for their cellular signaling capabilities, have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling, facilitating cancer cell proliferation, survival, and adaptation to hypoxia. On the other hand, ROS can promote antitumorigenic signaling and trigger oxidative stress–induced cancer cell death. To hyperactivate the

  • Renal cell carcinoma Nature Reviews Disease Primers

     · A common variant at 8q24.21 is associated with renal cell cancer. Nat. Commun. 4, 2776 (2013). Google Scholar 59. Schodel, J. et al. Common genetic variants at the 11q13.3 renal cancer

  • Targeting the tumor microenvironment and T cell

     · In this mini-review, we focus on the most recent studies describing mechanisms for manipulating the immunosuppressive TME and enhancing antitumor T cell responses through modulating metabolic pathways, and how these approaches can be used to improve the efficacy of immune checkpoint blockade and T cell ACT for the treatment of cancer.

  • REVIEW ARTICLE Nanocarriers as an emerging platform

     · REVIEW ARTICLE Nanocarriers as an emerging platform for cancer therapy Nanotechnology has the potential to revolutionize cancer diagnosis and therapy. Advances in protein engineering and materials science have contributed to novel nanoscale targeting approaches that may bring new hope to cancer patients.

  • Single Cell Sequencing Research ReviewIllumina

     · Baslan T and Hicks J. Unravelling biology and shifting paradigms in cancer with single-cell sequencing. Nat Rev Cancer. 201717 Benitez JA, Cheng S and Deng Q. Revealing allele-specific gene expression by single-cell transcriptomics. Int J Biochem Cell Biol. 201790 Haque A, Engel J, Teichmann SA and Lonnberg T.

  • Estimation of immune cell content in tumor BMC Cancer

     · Single-cell RNAseq data. We downloaded the single-cell RNA-seq data from Puram et al. [] which generated expression data of 6,000 single cells from head and neck squamous cell carcinoma (HNSCC) patients.By reviewing all published single-cell RNA-seq data (up to Dec 2018) in cancer, we found that this dataset covered the most diverse stromal, malignment and immune cells in the tumor

  • A Perspective on Cancer Cell Metastasis Science

     · Metastasis causes most cancer deaths, yet this process remains one of the most enigmatic aspects of the disease. Building on new mechanistic insights emerging from recent research, we offer our perspective on the metastatic process and reflect on possible paths of future exploration. We suggest that metastasis can be portrayed as a two-phase process The first phase involves the physical

  • Analysis of Cell Free DNA in Urine for Cancer Diagnosis

     · The Analysis of Cell Free DNA in Urine for Cancer DiagnosisA Prospective Alternative to Liquid Biopsy? Tuesday, March 9, 2021. The National Law ReviewNational Law Forum LLC 4700

  • Regulation of cancer cell metabolismPubMed

    Abstract. Interest in the topic of tumour metabolism has waxed and waned over the past century of cancer research. The early observations of Warburg and his contemporaries established that there are fundamental differences in the central metabolic pathways operating in malignant tissue. However, the initial hypotheses that were based on these

  • The tumour-induced systemic environment as a critical

    The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis. Nat Cell Biol. 2014 Aug16 (8) 717-27. doi 10.1038/ncb3015.

  • Therapeutic approaches to enhance natural killer cell

     · This poster is adapted from the following review Therapeutic approaches to enhance natural killer cell cytotoxicity against cancer the force awakens. Nat. Rev. Drug Discov. 14, 487–498 (2015). The poster content is editorially independent and the sole responsibility of Nature Publishing Group.

  • Liquid biopsies come of age Nature Reviews Cancer

     · Raised cfDNA levels were first reported in the serum of patients with cancer in 1977 (Ref. 5 ) cfDNA concentrations can also be raised in other physiological conditions or clinical scenarios

  • Targeted Therapies and Biomarkers in Small Cell Lung Cancer

     · Small cell lung cancer (SCLC) is an aggressive malignancy characterized by rapid growth, early metastasis, and acquired therapeutic resistance. A majority of patients with SCLC have extensive-stage (ES) disease, defined as the presence of metastatic disease outside the hemithorax at first diagnosis. SCLC has been considered “a graveyard for drug development,” with chemotherapy

  • The cell cycle and cancerWilliams2012The Journal

     · The cell cycle engine is a promising diagnostic and therapeutic target in cancer because it lies downstream at the convergence point of complex oncogenic signalling networks and its deregulation is central to the aberrant cell proliferation that characterizes all cancers.

  • Metabolic Frugality Marks Cancer Cells Home Cell Press

     · Altered cell metabolism is ubiquitous in cancer cells however, it remains challenging to exploit these alterations for cancer therapy. A new study reveals that metabolic alterations to the urea cycle promote tumor growth but unexpectedly also trigger mutations that mark cancer

  • Nature Cancer Nature Portfolio Cancer Community

     · The type 1 NKT cell stimulating glycolipid α-galactosylceramide (α-GalCer) was first identified by the Pharmaceutical Research Laboratory of Kirin Brewery in a screen for novel anti-tumor agents. Based on promising preclinical data it was tested as an anticancer drug in multiple clinical studies.

  • Nature reviews. Cancer (NAT REV CANCER)ResearchGate

    Inhibiting these kinases was believed to sensitize tumour cells to cancer treatments that damage DNA, because in the absence of checkpoints and efficient DNA repair, the response would switch to

  • NK cell-based cancer immunotherapy from basic biology to

     · NK cell biology. NK cells were identified over four decades ago as lymphocytes with innate ability to lyse tumor cells without the need for prior sensitization [8,9,10].NK cells can trigger target cell death by releasing cytotoxic granules containing granzymes and perforin and through death receptor-mediated pathways (e.g., FasL/Fas) [].NK cells also play immunomodulatory functions by

  • Tumour-cell invasion and migration Nature Reviews Cancer

     · Cancer cells disseminate from the primary tumour either as individual cells, using amoeboid- or mesenchymal-type movement, or as cell sheets, strands and clusters using collective migration

  • Adoptive cell transfer as personalized immunotherapy for

     · Adoptive cell therapy (ACT) is a highly personalized cancer therapy that involves administration to the cancer-bearing host of immune cells with direct anticancer activity. ACT using naturally occurring tumor-reactive lymphocytes has mediated durable, complete regressions in patients with melanoma, probably by targeting somatic mutations exclusive to each cancer.

  • Targeting the tumor microenvironment and T cell

     · Introduction. During the past decade, the development and increased use of cancer immunotherapies has resulted in impressive clinical benefits. Function blocking antibodies targeted to the immune checkpoint molecules PD-1/PD-L1 and CTLA-4 have been approved by the US Food and Drug Administration for the treatment of advanced melanoma, non-small cell lung cancer, renal cell

  • Classifying Cancers Based on T-cell Cancer Research

    Cancer immunotherapy may become a major treatment backbone in many cancers over the next decade. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Thus, the tumor has many strategies to evade an immune response. It has been proposed that four different types of tumor microenvironment exist based on the presence or absence of tumor

  • Nature Reviews Cancer Impact Factor IF

    Nature Reviews Cancer Impact Factor, IF, number of article, detailed information and journal factor. ISSN X.

  • Ivaska cell adhesion and cancer LabIntegrins, matrix

    Related publications from the lab Sahgal P et al., (2019), J Cell Sci Moreno-Layseca et al., (2019) Nat Cell Biol (review) Hamidi H, Ivaska J (2018), Nat Cancer Reviews Alanko et al., (2015), I’ve been a PhD student in the lab since September 2019, studying the interplay between cancer cell adhesion, cytoskeletal dynamics and membrane

  • Natural killer cells and other innate lymphoid cells in cancer

     · Several studies on large numbers of patients have assessed the prognostic value of peripheral NK cell cytotoxicity in patients with cancer. A correlation between poor NK cell function and the

  • Metabolic pathways promoting cancer cell survival and

     · Oncogenic drivers are highlighted in green, while tumour suppressors are shown in red. Important metabolic enzymes are highlighted in blue. Classic cancer metabolic pathways are shown in

  • Immunosuppressive cell death in cancer Nature Reviews

     · In their recent Review article ( Immunogenic cell death in cancer and infectious disease. Nat. Rev. Immunol. 17, 97–111 (2017)) 1, Galluzzi et al. discussed the molecular mechanisms underlying

  • CAR T cell immunotherapy for human cancer Science

     · Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field has rapidly advanced from a promising form of immuno-oncology in preclinical models to the recent commercial approvals of chimeric antigen receptor (CAR) T cells to treat leukemia and lymphoma. This Review describes

  • Cancer stem cells A brief review of the current status

     · Cancer stem cells (CSCs) first identified in acute myeloid leukemia (AML) by Bonnet and Dick in 1997 are shown to be similar concerning normal stem cells which have the capability of self-renewal and differentiation into other cell types (Bonnet and Dick, 1997 Ailles and Weissman, 2007).The study demonstrated that AML CSCs with the phenotype CD34 CD38 − constituting approximately

  • T-cell–based Immunotherapy Adoptive Cell Transfer and

    Tumor immunotherapy has had demonstrable efficacy in patients with cancer. The most promising results have been with T-cell–based therapies. These include adoptive cell transfer of tumor-infiltrating lymphocytes, genetically engineered T cells, and immune checkpoint inhibitor antibodies. In this review, we describe the different T-cell–based strategies currently in clinical trials and put

  • The extracellular matrix A dynamic niche in cancer

    The past 20 years have seen cancer biology and development biology converge, and both fields have greatly benefited from each other’s research progress (Xie and Abbruzzese, 2003 Radtke and Clevers, 2005 Blanpain et al., 2007).Retrospectively, such a convergence is inevitable, as many of the same cell behaviors and processes essential for embryonic development are also indispensable for

  • A Perspective on Cancer Cell Metastasis Science

     · Metastasis causes most cancer deaths, yet this process remains one of the most enigmatic aspects of the disease. Building on new mechanistic insights emerging from recent research, we offer our perspective on the metastatic process and reflect on possible paths of future exploration. We suggest that metastasis can be portrayed as a two-phase process The first phase involves the physical

  • Immunogenic cell death in cancer and infectious disease

    Similarly, cancer cells often escape immunosurveillance owing to defects in the molecular machinery that underlies the release of endogenous adjuvants. Here, we review current knowledge on the mechanisms that underlie the activation of immune responses against dying cells